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The PSA produced from cancerous cells appears to escape an enzymatic processing that cleaves the bond between PSA and the protein that binds to it. Men with prostate cancer have a greater fraction of bound PSA and a lower amount of unbound (free) PSA compared with men without prostate cancer. Therefore, the free/total PSA ratio (percent free PSA) can be used as an aid in distinguishing prostate cancer from PSA elevated benign disease. #prostate

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